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The diffrence is Nasal contains 10MG of Phenylephrine hydrochloride in each tablet, and Sinus contains 5MG of Phenylephrine HCI (which I assume is the same as Phenylephrine hydrochloride) and also 325MG of. Catapres is used in the treatment of high blood pressure, so it’s common for people to assume it must be a beta-blocker. Catapres is used in the treatment of high blood pressure, so it’s common for people to assume it must be a beta-blocker. Catapres tablets are taken by mouth, with or without food, usually twice, once in the morning and once at bedtime. Catapres tablets are taken by mouth, with or without food, usually twice, once in the morning and once at bedtime. It is not known if Catapres is safe and effective in children younger than 12 years of age Treatment duration has varied across clinical trials, generally ranging from 3 to 10 weeks. 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